EVALUATION OF MACULAR THICKNESS IN DIABETIC MACULAR EDEMA TREATED WITH 0.1% NEPAFENAC WITH CONTROL AND UNCONTROLLED GLYCEMIC LEVEL

Abstract

Objective: To evaluate the effect of 0.1% Nepafenac on macular thickness and visual acuity in diabetic macular edema with controlled and uncontrolled glycemic controls. 

 Methodology: A Qusai experimental study design was used. This study included 60 patients with age above 15 years. Data was collected at the Department of Ophthalmology in Madina Teaching Hospital Faisalabad. 30 participants with controlled sugar levels were in group 1 remaining 30 participants with uncontrolled blood sugar were in group 2. Both groups were treated with 0.1% Nepafenac eye drops. Visual acuity and macular thickness was evaluated before and after treatment with the help of questionnaire. Participants were for follow up at 4^th and 6^th week. Statistical analysis was done by using repeated measure ANOVA and Independent sample t-test.

Results: The mean value of macular thickness at baseline was 441.6667 in controlled sugar groups while 518.4000 in uncontrolled after 4 weeks of using nepafenac was 433.7000 in control sugar group and 516.0333 in uncontrolled and after 6 weeks was 425.7667 and 512.4667 in control and uncontrolled sugar level groups respectively and p value was (p= .000). The mean  of visual acuity at baseline was .7533 and .8367  while after 4 weeks  was .7533 and .8367 while after six weeks was .6000 and .7000 in control and uncontrolled respectively. P value for visual acuity at baseline, after 4 and six weeks was .024, .024 and .0234 respectively in control and uncontrolled sugar groups.

Conclusion: Topical nepafenac is effectivce in improving macular thickness and vision in accordance with different blood sugar levels. Topical nepafenac works more efficiently if patient has controlled blood sugar level.