EFFECT OF AVASTIN AND PAN RETINAL PHOTOCOAGULATION ON INTRAOCULAR PRESSURE IN DIABETIC RETINOPATHY

Abstract

Purpose: To assess and compare the effect of intra vitreal avastin and pan retinal photo coagulation on intra ocular pressure in proliferative and non-proliferative diabetic retinopathy patients.

Methodology: A Quasi experimental study was conducted at Madina Teaching Hospital Faisalabad. A Non-Probability purposive sampling technique was used. The study was conducted from September 2021 to June 2022. 30 diabetic retinopathy patients of both genders and age ranges from 15 years to onwards were included. Self-designed proforma was used. Intra ocular pressure was recorded by using Gold man applanation tonometer technique. Patients were divided into two groups. One group was treated with intra vitreal avastin and other group was treated with pan retinal photo coagulation therapy. Intra ocular pressure was recorded at base line, immediately within 30 minutes after therapy, at 3^rd day and after 1 week. Statistical analysis was done by using repeated measure ANNOVA and independent sample t-test.

Results: The intra ocular pressure was raised after intra vitreal avastin and pan retinal photo coagulation therapy with a p<0.05 (p=0.00). In comparison of effect of intra vitreal avastin and pan retinal photo coagulation on intra ocular pressure at the base line p>0.05 (p=0.661) was non-significant, at first follow up p<0.05 (p=0.00) was significant, at second follow up p>0.05 (p=0.070) was non-significant, and at third follow up p>0.05 (p=0.729) with a mean value at base line was 15.0867, 15.4667, at first follow up was 22.8667, 18.8000, at second follow was 18.9133, 17.1133 and at third follow up was 15.3867, 15.6933 respectively.

Conclusion: There was an impermanent rise in intra ocular pressure after application of avastin and laser which returns to its base line value at 3^rd follow up. In comparison of both therapies, pan retinal photo coagulation is considered to be safer.