EFFECT OF CORTICOSTERIOD NASAL SPRAY ON TEAR FILM STABILITY IN ALLERGIC RHINITS

Abstract

Objective: The aim of study is to check the effect of nasal steroid treatment on tear film stability in allergic rhinitis patients and compare the effect of fluticasone furoate 27.5mcg with momatesone furoate 50mcg nasal spray.

Methodology: A Quasi-Experimental study design was used. 60 participants of both genders diagnosed with Allergic rhinitis, age ranging from 15-30 years was included. Data was collected from Department of Ophthalmology at Madina Teaching Hospital, Faisalabad. Schirmer and tear breakup time was performed on each participant before prescribing the nasal spray. Then a patient was divided into 2 groups, 30 in each group. Fluticasone furoate was prescribed to group 1 and momatesone furoate to group 2 for 1 month. Follow up was taken on 2^nd and 4^th week of use. Schirmer test and TBUT was performed on both groups accordingly. Data analysis was done by repeated measure ANOVA and independent sample t test.

Results: Results showed that both test values was decreased at baseline which indicate that patients were having instability of tear film as p < 0.05 (P=0.00), while at 2^nd and at 4^th week p value was significant within groups as p <0.05 (P=0.00). When comparing the both groups at base line the mean value of schirmer test in flucatisone furoate and momatesone was 7.666 and7.33 respectively, at 2^nd week was 10.544, 10.360, at 4^th week was 15.266, 14.666 respectively. The mean value of (TBUT) in momatesone and flucatisone groups was 6.353, 6.293 at base line, 6.386, 7.080 at 2^nd week and 8.900, 9.373 at 4^th week respectively.

Conclusion: Both drugs momatesone furoste 50 mcg and flucatisone fuorate 27.5mcg improve tear film stability equally so any of the drugs can be used signally for treatment.