Synthesis, Characterization of Poly[bis(diethyl amino phenol)phosphazenes] and Biomedical Applications for Social Benefit of Humanity

Abstract

Recently, biomedical applications gained much attention due to their application and significance for humanity such as drugs deliver, tissue engineering etc. Researcher found that polymers are the best materials for biomedical applications, but polyphosphazenes are the versatile class of biomaterials being extensively applied in multitude of biomedical applications due to their unique properties such as easily biodegradable and non-toxicity, biocompatible and meet the requirement of human body. In this study, poly[bis(diethyl amino phenol)phosphazenes] is synthesized  in two steps. In the first step polydichlorophosphazenes (PDCP) is synthesized from hexacholorocyclotriphosphazenes (HCCP) using AlCl₃ catalyst and then chlorines groups of PDCP are replaced with hydroxy groups of phenol and diethylamine respectively.  HNMR and GPC proved the successful synthesis of poly[bis(diethyl amino phenol)phosphazenes]. Later, hydrolytic degradation of Poly[bis(diethyl amino phenol)phosphazenes] is investigated  for biomedical applications such as hydrolytic degradation for drugs delivery etc for the social benefit of human beings.